Product name: Piracetam

CAS: 7491-74-9

MF: C6H10N2O2

MW: 142.16

EINECS: 231-312-7

Product Categories: Miscellaneous; API's

mp 151-152,5 C

storage temp. Store at RT

Appearance: White crystalline powder. Melting at 151.5-152.5 ° C. Soluble in water, slightly soluble in ethanol, almost insoluble in ether. Odorless, slightly bitter taste.

Usage: Treatment for acute and chronic cerebrovascular disease, brain trauma, a variety of toxic encephalopathy and other causes of memory loss and mild to moderate brain dysfunction. It could also be used for children with mental retardation.

Medicine for the cool oil, painkillers, etc., but also for toothpaste, toothpowder, candy, beverages, spices

Piracetam description:

Piracetam is also known as brain rehabilitation, pyridine acetamide, pyrazole pyrrole ring ketone, is a brain metabolism to improve drugs, are γ-aminobutyric acid cyclization derivatives, the central role of selective strong, limited to the brain Function (memory, consciousness, etc.) improvement, the role of mental excitement, no psychiatric side effects, no dependence. Can prevent or protect animals from hypoxia caused by retrograde amnesia, but also significantly antagonized barbiturate inhibition of the central nervous system, can promote brain cell metabolism, increase the brain of amino acids, protein, glucose absorption and utilization, with activation , Protect and repair the role of brain cells, can promote the brain ADP into ATP, to improve the metabolism of energy supply in the brain. It affects the excitatory transmission of cholinergic neurons and promote the synthesis of acetylcholine. Piracetam can resist physical factors and chemical factors caused by brain damage, improve learning, memory and memory. Can be improved by the hypoxia caused by retrograde amnesia. Oral easy to absorb, 30 to 40 minutes after the peak plasma concentration, protein binding rate of 30%, clear half-life of 4 to 6 hours, easy through the blood-brain barrier to reach the brain and cerebrospinal fluid. After oral administration can not be decomposed by the liver, in the form of excretion from the urine and feces. Mainly used for brain disease caused by memory and mental retardation, organic dementia and mental retardation in children, mild to moderate Alzheimer's have a certain effect, but for those with severe invalid. On the improvement of functional brain dysfunction syndrome symptoms also have a certain effect. Piracetam can also be used for encephalitis, carbon monoxide, pesticides and alcoholism consciousness recovery, intravenous or infusion can be used.

Oral administration can be absorbed quickly from the digestive tract, and burst into the blood, and through the blood-brain barrier to reach the brain and cerebrospinal fluid, cerebral cortex and olfactory bulb concentration is higher than the brain stem concentration. This product is easy through the placental barrier. After oral administration, the plasma concentration reached a peak at 30 to 45 minutes, the plasma protein binding rate was 30%, the half-life t1 / 2 was 5 to 6 hours, and the apparent distribution volume (Vd) was 0.6 L / kg. Piracetam can not be decomposed by the liver after oral administration, in the form of excretion from the urine and feces. Kidney clearance rate was 86 ml / min. Stool discharge is about 1% to 2%.

Piracetam Usage and Dosage :

Oral administration: each 800 ~ 1600 mg, 3 times a day, 3 to 6 weeks for a course of treatment, pediatric dosage halved.

Intramuscular injection: each 1 g, 2 to 3 times a day.

Intravenous: each 4 g, 1 day.

Intravenous infusion: each 4 ~ 8 g, 1 day. With 5% glucose injection or 0.9% sodium chloride injection diluted to 250 ml. Elderly and child use halved.

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