CAS 96-48-0 Gamma-Butyrolactone 

Alias: Gamma Butyrolactone, 1, 4- Butyrolactone, γ -Butyroladone, GBL, BLO 

Purity : 99.0% 

CAS Registry Number: 96-48-0 

Einecs No: 202-509-5 

MF: C4H6O2 

MW: 86.09 

Melting Point:-44°C 

Boiling Point:206°C 

Flash Point:99.2°C 

Ignition temperature:455°C 

Refractive Index:nd20 :1.434~1.440 

Density 1.12 g/mL at 25 ° C(lit. ) 

Storage temp. 2-8° C 

Chemical Properties: Colourless oily liquid 

Appearance:Colorless clear oily liquid with acetone-like odor 

Product Categories: Pharmaceutical Intermediates;Heterocycles;Miscellaneous Reagents  

Uses:

(1) GBL can be used to produce a-pyrrolidone, 1-Methyl-2-pyrrolidinone , polyvinyl pyrrolidone, and α-Acetyl-γ-butyrolactone, etc.

 (2)GBL can be used as anaesthetic and tranquilizer, used to produce ciprofloxacin and interferon, as the intermediate of vitamin and rolicyprine;

(3) GBL is the intermediate of plant growth stimulator and insecticide.

(4)GBL is a good antioxidant, plasticizer, extractant, adsorbent, dispersant, fixative and curing agent; Moreover, it can also be used in battery, capacitor and development of color film.

Product Description:

Gamma-Butyrolactone (γ-butyrolactone or GBL) is a hygroscopic colorless liquid with a weak characteristic odor which is soluble in water. GBL is a common solvent and reagent in chemistry as well as being used as a flavouring, as a cleaning solvent, as a superglue remover, and as a solvent in some wet aluminium electrolytic capacitors. In humans it acts as a prodrug for GHB, and it is used as a recreational intoxicant with effects similar to alcohol.

GBL has been found in extracts from samples of unadulterated wines.[3] This finding indicates that GBL is a naturally occurring component in some wines and may be present in similar products. The concentration detected was approximately 5 μg/mL and was easily observed using a simple extraction technique followed by GC/MS analysis. GBL can be found in cheese flavourings but typically results in a content of 0.0002% GBL in the final foodstuff.

GBL is a lactone. It is hydrolyzed under basic conditions, for example in a sodium hydroxide solution into sodium gamma-hydroxybutyrate, the sodium salt of gamma-hydroxybutyric acid. Under acidic conditions it forms an equilibrium mixture of both compounds. These compounds then may go on to form a polymer. When treated with a non-nucleophilic base, like lithium diisopropylamide, GBL can become an alpha-carbon nucleophile. The related compound caprolactone can be used to make a polyester in this manner.

GBL is not active in its own right; its mechanism of action stems from its identity as a prodrug of GHB.

The hypnotic effect of GHB is enhanced by combination with alcohol. A 2003 rat study showed that GBL in combination with ethanol showed a potentiated hypnotic effect, as the sleep-timing measure was longer than both of the individual components combined

GBL is rapidly converted into GHB by paraoxonase (lactonase) enzymes, found in the blood.[7][8] Animals which lack these enzymes exhibit no effect from GBL.[7] GBL is more lipophilic (fat soluble) than GHB, and so is absorbed faster and has higher bioavailability. Because of these pharmacokinetic differences, GBL tends to be more potent