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Acadesine

Synonyms:Imidazole-4-carboxamide,5-amino-1-b-D-ribofuranosyl- (6CI,7CI,8CI); 1-Ribosyl-4-carboxamido-5-aminoimidazole; 1-b-D-Ribofuranosyl-5-amino-4-imidazolecarboxamide; 5-Amino-1-ribosyl-4-imidazolecarboxamide; 5-Amino-1-b-D-ribofuranosylimidazole-4-carboxamide; 5-Amino-4-imidazolecarboxamide ribofuranoside; 5-Amino-4-imidazolecarboxamideriboside; 5-Aminoimidazole-4-carboxamide 1-(b-D-ribofuranoside); AIC-Riboside; AICA-Riboside; Acadesine; Arasine; NSC 105823; GP 1-110;

CAS Registry Number:2627-69-2

EINECS:220-097-5

Molecular Formula:C9H14N4O5

Molecular Weight:258.23126

Molecular Structure:

This structure is also available as a 2d Mol file

Appearance:Solid

Density:2.06 g/cm3

Boiling Point:726.3 °C at 760 mmHg

Melting Point:214-215 oC

Flash Point:393.1 °C

Storage Temperature:20°C

Refractive index:1.821

Solubility:H2O: >10 mg/mL

Biological Activity:Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes.

Usage:Acadesine (CAS NO.2627-69-2) is used for the treatment of acute lymphoblastic leukemia and may have applications in treating other disorders such as diabetes.